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1996-03-09
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Document 0404
DOCN M9650404
TI [Relationship between chronic liver diseases and hepatitis C in Burundi
adults]
DT 9605
AU Aubry P; Larouze B; Muhirwa G; Henzel D; Ndabaneze E; Nsabimana JM;
Departement de Medecine Interne, Centre Hospitalier; Universitaire
Kamenge, Bujumbura, Burundi.
SO Med Trop (Mars). 1995;55(3):235-7. Unique Identifier : AIDSLINE
MED/96141169
AB A case/control study was conducted in Bujumbura, Burundi, from 1991 to
1992 to assess the relationship between chronic liver disease and
hepatitis C virus (HCV). Patients presenting chronic liver disease (n =
80) were selected based on clinical, laboratory, ultrasonographic,
and/or endoscopic findings. Patients with AIDS or hepatocellular
carcinoma were excluded. Controls (n = 159) matched with regard to age
and sex were recruited from outpatients who had blood tests at a liver
disease clinic. Patients and controls were tested for anti-HCV
antibodies by ELISA and LIA. Screening for hepatitis B virus (HBs
antigen, anti-HBs and anti-HBc antibodies) and human immunodeficiency
virus (HIV) was achieved by ELISA with confirmation of HIV infection by
LIA. The incidence of anti-HCV antibodies was significantly higher in
patients (55.0%) than controls (33.3%) (p < 0.001). The incidence of HBs
antigens was significantly higher in patients (28.8%) than controls
(7.5%) (p < 0.0001). The incidence of anti-HIV antibodies was not
significantly different in the two groups. Multifactorial analysis
indicated that anti-HCV antibodies and HBs antigens were risk factors
for chronic liver disease, but did not detected a significant
interaction between these two risk factors. Prevention of hepatitis C
and B would reduce the incidence of chronic liver disease but cost
currently limits widespread use of this approach.
DE Adolescence Adult Aged Burundi Case-Control Studies Chronic Disease
English Abstract Female Hepatitis C/*COMPLICATIONS/IMMUNOLOGY
Hepatitis C Antibodies/BLOOD Human Incidence Liver
Diseases/IMMUNOLOGY/*VIROLOGY Male Middle Age Multivariate Analysis
Seroepidemiologic Methods Urban Health JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).